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Clinical resource

Sleeping Pills Side Effects

Though sleeping pills are effective in bringing sleep, they often have physical side effects. The most common problems are dizziness, daytime drowsiness, and a prolonged feeling of grogginess

Medically reviewed byDr. Sarah Boss, MD
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Quick Summary

  • Sleeping medicines differ in their effects and risks; sedation, falls and impaired alertness are important concerns.
  • Benzodiazepines and Z-drugs may cause physical dependence. Routine stopping should be planned with the prescriber.
  • Complex sleep behaviors with zolpidem, zaleplon or eszopiclone require stopping that medicine and immediate prescriber contact. Abnormal breathing or inability to wake requires emergency help.

Insomnia is very often dealt with sleeping pills, and the side effects can vary from mild to serious, affecting both physical and mental health. Overreliance on these drugs can lead to falls, memory problems, and even dependency, so it’s important to know the risks. Though it works in the short term, sleeping pills are not a reliable cure for all sleep disorders.

Sedative hypnotics (sleeping pills) are medications used to treat sleep disorders, most commonly insomnia. These act by targeting the central nervous system, slowing down brain activity to induce relaxation and make you sleep. Most of these pills are benzodiazepines (e.g., temazepam), non benzodiazepine hypnotics (e.g., zolpidem) or melatonin receptor agonists (e.g., ramelteon). Each class works differently, but all aim to achieve the same goal: It helps to facilitate a restful night’s sleep.

There are sleeping pills that are meant to be used over a short period to treat acute sleep disturbances, and then some are prescribed for more lengthy issues. But they work and are safe in different ways for different people, depending on factors like age, overall health, and the reason for sleep problems.

Why Sleeping Pills Use Is On The Rise

Insomnia is the most common reason people take sleeping pills. Millions of people around the world suffer from insomnia, and it can be caused by stress, anxiety, or other medical conditions such as chronic pain or depression.

Sleep problems related to shift work, jet lag, restless legs or obstructive sleep apnea require assessment of the specific cause. Sedative sleeping pills do not treat obstructive sleep apnea and some can worsen breathing; they should not be used as a substitute for appropriate treatment.

Though sleeping pills are effective in bringing sleep, they often have physical side effects. The most common problems are dizziness, daytime drowsiness, and a prolonged feeling of grogginess (a “hangover effect”). Dry mouth, headaches, and gastrointestinal upset (ie, nausea or constipation) are other possible side effects.

Effects differ by medicine, dose, age and health. Women clear zolpidem more slowly on average, which informs its dosing recommendations; this should not be generalized to every sleeping pill.

Psychological Side Effects: Short-Term Impacts

Psychological side effects include confusion, memory problems, or difficulty concentrating in older adults. In some cases, some sleeping aids cause users to wake up at night, and experience vivid dreams or nightmares, particularly after the drug’s effects wear off.

Zolpidem, zaleplon and eszopiclone can rarely cause complex sleep behaviors, including sleepwalking or driving while not fully awake, with serious injury or death. If this occurs, stop that medicine and contact the prescriber immediately. This specific safety instruction differs from routine planned withdrawal after regular use.

How Prolonged Use Can Affect Your Physical Health

Some sleeping medicines, especially benzodiazepines and Z-drugs, can cause tolerance and physical dependence. These are not inevitable with every medicine and do not automatically mean addiction. Do not raise the dose without the prescriber’s advice.

Sedatives can worsen breathing in some people, particularly with sleep apnea, lung disease, opioids or alcohol. Risks depend on the medicine and circumstances; claims that all sleeping pills weaken immunity are not established.

Sedation, dizziness and poor coordination increase falls and fracture risks, particularly in older adults. Observational links with cardiovascular illness do not by themselves prove that every sleeping medicine causes heart attacks.

Are Sleeping Pills Bad For Your Brain

Sedatives may impair attention and memory, especially in older adults. Some observational studies associate long-term use with dementia, but this does not establish that the medicines cause dementia; sleep problems, illness and other factors complicate the evidence.

Medicines differ in their effects on sleep and alertness. New or persistent mood, memory or sleep problems warrant a review of the medicine and possible underlying conditions; they should not be attributed automatically to disrupted brain function.

Maternal Health Risks

Sleeping pills can have special risks for pregnant women. Many sleeping medications pass through the placental barrier and could affect the mother and the developing baby. Expectant mothers may experience common side effects, such as increased drowsiness, dizziness, and nausea. They can impair daily functioning and put you at risk for accidents, such as a fall.

Also, some sleeping pills, such as barbiturates and benzodiazepines, can become habit-forming in the mother if taken often during pregnancy. The withdrawal symptoms that occur if the medication is suddenly stopped can complicate childbirth and postpartum recovery.

Effects On The Developing Baby

Pregnancy risks differ substantially between medicines, dose and timing, and observational findings may reflect the underlying illness as well as treatment. Discuss the specific medicine with the prescriber or maternity team rather than assuming that all sleeping pills cause birth defects or developmental delay.

Sleeping pills at later stages can cause neonatal sedation or withdrawal symptoms in newborns if given during pregnancy. For example, babies who have been exposed to benzodiazepines in the womb may be sedated, and have trouble breathing or feeding after birth.

However, given the risks involved, healthcare providers often recommend trying nonmedical sleep aids during pregnancy. Although sleeping pills may sometimes be necessary, they are only prescribed where it is judged to be essential, and in the minimally effective dose for the shortest time to minimize potential harm.

Which Sleeping Pills Are The Most Harmful

Not all sleeping pills are the same and some pose much higher risks than others. Barbiturates, an older class of sedatives, are among the most dangerous because their effects are very strong. While their use is diminishing, these pharmaceuticals are still prescribed in the rarest of cases and abuse can result in serious problems, such as respiratory depression and coma.

Benzodiazepines and Z-drugs have distinct benefits and risks. Dependence, next-day impairment and serious reactions can occur even during prescribed use. Z-drugs are not universally safer, and complex sleep behaviors can occur after a single dose.

That being said, over-the-counter (OTC) options, such as diphenhydramine (found in Benadryl or some sleep aids), are also not risk-free. Long-term use of these drugs can cause side effects including problems with memory and confusion and increased risk of falling, especially in elderly people. In addition, these medications are often thought of as ‘safe,’ causing people to accidentally use them in large doses as well.

Overdose And Severe Reactions: What To Watch For

Extreme sleepiness, inability to wake or slow or abnormal breathing after sleeping pills is an emergency. Call 112 in Spain or the EU, or the local emergency number; do not wait for the person to sleep it off. Stay with them, follow dispatcher instructions and do not induce vomiting. Alcohol and opioids increase the danger.

Some sleeping aids cause severe allergic reactions, though they are rare. A severe rash, difficulty breathing, or swelling of the face or throat require immediate medical attention.

Another important risk is drug interactions. Most sleeping pills can react with other medications, for example, antidepressants, and antihistamines, resulting in exaggerated sedation and perhaps dangerous side effects. However, it is always important to speak with a healthcare provider to check that a single use is safe, particularly if you have a health problem or are on other substances.

Sleeping Pills: Medical Conditions And Situations To Avoid

Certain medical conditions make sleeping pills especially risky. For example, people with sleep apnea should usually avoid sedatives because they can make breathing problems during sleep worse. Just as with substance abuse or addiction, those with a history of addiction are more likely to become dependent on sleeping pills too.

Another group at risk from sleeping pills is older adults. People older than 65 have age-related changes in metabolism, and thus are more sensitive to medications, which gives them greater rates of also having grogginess, confusion, and fall risks. As mentioned earlier, pregnant women should use sleeping pills only with great caution, because they can be harmful for both mother and baby.

Never mix sleeping pills with alcohol or recreational drugs as this can dramatically increase the chance of an overdose, or of nasty side effects. Even with prescription medications, you need to review them to make sure you’re not going to interact with other drugs that will increase sedative effects or make it not safe to stay awake.

Non-Medical Sleep Aids And Behavioral Therapies.

Nonmedical sleep aids and behavioral therapies are usually effective for those looking for safer alternatives. Cognitive Behavioral Therapy for Insomnia (CBT-I) is a tested approach that educates individuals on how to recognize and alter thoughts and offers strategies that improve rest. 

Regular sleep timing, reducing evening caffeine and a calming routine can help. Melatonin and herbal products can also cause side effects or interactions and are not automatically safe, particularly in pregnancy. Ask a pharmacist or prescriber before combining them with other medicines.

If you have chronic or severe sleep problems, the best thing to do is work with a healthcare provider to create a personalized plan that involves the least amount of medication and promotes long-term sleep health.

How To Identify Dependency And Misuse

It is easy to become dependent on sleeping pills, sometimes starting with occasional use to help you sleep through a sleepless night. The fact is over time individuals may require higher and higher doses to achieve the same effect, a clear indicator of tolerance. It is a dependency because you rely on the medication to fall asleep and have withdrawal symptoms when you try to stop. Rebound insomnia, anxiety, irritability, or even physical discomfort may be among these symptoms.

One more red flag is to use of sleeping pills for a purpose other than intended, including the use of pills while awake for relaxation or taking the pills with other substances like alcohol. Equally concerning is emotional dependency, in which the person can’t function without the medication.

How To Safely Stop Taking Sleeping Pills

For routine discontinuation after regular benzodiazepine or Z-drug use, agree an individual taper with the prescriber; abrupt stopping can cause serious withdrawal. Other sleep medicines have different stopping advice. A severe allergic reaction or complex sleep behavior needs immediate medical advice and the specific safety action for that medicine.

For people with very serious dependency medical detox programs can provide further support. With supervised environments, these programs help to carefully monitor the withdrawal symptoms and can assist with appropriate care to reduce the risk of complications during withdrawal.

CBT-I is an evidence-based first-line treatment for chronic insomnia and can support longer-lasting improvement. It is not generally faster acting than sedative medication. Peer support may complement professional care but does not replace a medication review.

If you are worried about continued side effects from sleeping pills, you need to speak to a healthcare provider. This will assist in identifying the underlying health issues and making strategies to bring back holistic well-being.

Questions

Frequently Asked Questions

Do Sleeping Pills Cause Allergic Reactions?
Some people can have allergic reactions to sleeping pills, but that’s rare. Allergic reaction symptoms could include itching, rash, swelling, dizziness or trouble breathing. Certain medications (such as zolpidem or benzodiazepines) can increase your risk of experiencing these reactions, and you should seek immediate medical attention. Before you start a sleeping pill, it’s important to tell your doctor about any allergies.
Do Sleeping Pills Affect Your Heart Health?
Effects vary by medicine and individual health. Some can lower blood pressure or interact with medicines that affect heart rhythm. Observational associations do not prove that all sleeping pills cause cardiovascular disease; ask the prescriber about the specific medicine.
Are Sleeping Pills Addictive To Short-Term Users?
Some medicines can cause physical dependence during short-term prescribed use, but dependence is not the same as addiction. Use the agreed dose and duration, and discuss stopping with the prescriber. Risk differs between medicine classes.
Do Sleeping Pills Affect Hormones Like Melatonin?
Sleeping medicines have different mechanisms. Melatonin and melatonin-receptor medicines act on sleep-timing pathways, while other hypnotics work differently. It is not established that zolpidem or sedating antihistamines inevitably suppress natural melatonin production or permanently disrupt the body clock.
What Happens When Sleeping Pills Are Mixed With Mental Health Medications?
Taking sleeping pills may affect medications for depression, anxiety or bipolar disorder. Th,ese interactions can boost sedation, raise the risk of side effects or even flip the effect, of mental health therapies. For example, using sedatives together with antidepressants such as SSRIs can raise the chance of dizziness or confusion. It’s always important to tell your doctor about all the medications you’re taking to prevent dangerous drug interactions.

Editorial evidence

Evidence & sources

Selected clinical guidelines, peer-reviewed research, and public-health sources used in this article.

01National Institute on Drug Abuse. (2020). Benzodiazepines and opioids. National Institute on Drug Abuse.View source
02Sateia, M. J., Buysse, D. J., Krystal, A. D., Neubauer, D. N., & Heald, J. L. (2017). Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults. American Academy of Sleep Medicine.View source
View all 17 sourcesShow fewer sources
04Weich, S., Pearce, H. L., Croft, P., Singh, S., Crome, I., Bashford, J., & Frisher, M. (2014). Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: Retrospective cohort study. The BMJ.View source
05Glass, J., Lanctu00f4t, K. L., Herrmann, N., Sproule, B. A., & Busto, U. E. (2013). Sedative hypnotics in older people with insomnia: Meta-analysis of risks and benefits. JAMA Network.View source
06MedlinePlus. (2024). Insomnia. National Library of Medicine.View source
07Agency for Healthcare Research and Quality. (2015). Management of insomnia disorder in adults: Current state of the evidence. U.S. Department of Health and Human Services.View source
08MedlinePlus. (2024). Temazepam. National Library of Medicine.View source
09Centers for Disease Control and Prevention. (2024). Older adult fall prevention. CDC.View source
10National Center for Biotechnology Information. (n.d.). Zolpidem – StatPearls – NCBI Bookshelf.View source
11MedlinePlus. (2024). Zolpidem. National Library of Medicine.View source
12U.S. Food and Drug Administration. (2013). FDA drug safety communication: FDA approves new label changes and dosing for zolpidem products and a recommendation to avoid driving the day after using Ambien CR. U.S. Food and Drug Administration.View source
13National Health Service. (2022). Zopiclone: Side effects. National Health Service.View source
14Roth, T. (2012). Insomnia: Definition, prevalence, etiology, and consequences. New England Journal of Medicine.View source
15U.S. Food and Drug Administration. (2019, April 30). FDA adds Boxed Warning for risk of serious injuries caused by sleepwalking with certain prescription insomnia medicines. FDA.View source
16National Institute for Health and Care Excellence. (2023). Medicines associated with dependence or withdrawal symptoms: Safe prescribing and withdrawal management for adults. NICE.View source
17Centers for Disease Control and Prevention. (2024). Sleep and sleep disorders. Centers for Disease Control and Prevention.View source
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