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Clinical resource

Lyrica Addiction

What we don't know can often hurt us when it comes to prescriptions. The same goes for Lyrica, a potent painkiller and anti-anxiety drug previously thought to be non-addictive and completely safe for use.…

Medically reviewed byDr. Sarah Boss, MD
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Quick Summary

  • Lyrica, or pregabalin, is prescribed for neuropathic pain, fibromyalgia, anxiety, and epilepsy, but repeated misuse may lead to tolerance, dependence, and addiction.
  • Possible warning signs include taking more than prescribed, increasing doses, cravings, mood or sleep changes, memory problems, and neglecting work or personal care.
  • Sudden discontinuation may cause serious withdrawal symptoms, so professional assessment, supervised tapering or detoxification, ongoing therapy, and aftercare may be appropriate.

What we don’t know can often hurt us when it comes to prescriptions. The same goes for Lyrica, a potent painkiller and anti-anxiety drug previously thought to be non-addictive and completely safe for use. Abuse of Lyrica and other similar drugs often begins with a false sense of security around its safety that arises because of a limited understanding of its effects. Under this false pretense, millions of people kept using this medication, eventually developing an addiction.

Now classified as a schedule five drug, everyone knows its potential for abuse and addiction. Lyrica can cause physical dependence and addiction, including during prescribed use. Dependence means withdrawal can occur after stopping or reducing the dose; it does not inevitably lead to addiction, which involves impaired control and continued use despite harm.

Knowing the risks that accompany Lyrica use, the common symptoms of addiction and the available treatment options to overcome this issue is critical to saving yourself from long-term deterioration.

Lyrica or pregabalin is a prescription painkiller used to manage chronic pain disorders, such as neuropathic pain and fibromyalgia. It works by interrupting pain signals sent to the brain to offer pain relief. Additionally, the medication also helps in the treatment of generalized anxiety disorder and epilepsy. Lyrica became a more commonly prescribed drug amidst the global opioid epidemic as experts thought it to be a safer and less addictive painkiller. However, over time, the rate of Lyrica addiction has been rising across the world and even leading to mortalities and promoting suicidal behaviors. This has prompted healthcare professionals to raise awareness regarding recognizing Lyrica addiction in time and seeking treatment for it.

Following are some of the most common symptoms of Lyrica addiction:

  • Taking Lyrica regularly in ways that have not been prescribed by a doctor, such as using it without a prescription, in higher doses, or more frequently than needed
  • Loss of interest in activities or hobbies that you previously used to enjoy
  • Developing signs of Lyrica tolerance, such as the need to take progressively increasing amounts of this drug to experience the same effects
  • Unexplained weight loss or weight gain
  • Mood swings
  • Showing hostility or irritability when not under Lyrica’s influence
  • Memory loss
  • Changes in personal hygiene routines, sleep patterns, or commitment to daily obligations like school or work

If you or someone you love is showing the possible signs of Lyrica addiction, it is important to seek help right away. A professional can guide you about how to best support yourself or your loved one in entering treatment.

While Lyrica addiction can hit anyone, some people are at a higher risk than others. These include:

People with legal prescriptions

A lot of people who are using Lyrica with a legal prescription, such as for anxiety, convulsions, epilepsy, and insomnia, may get hooked on it and start abusing it.

Prisoners

Lyrica addiction is particularly prevalent in prisoners who trade it for other commodities, like cigarettes. These individuals commonly use Lyrica to overcome their mental health issues or briefly reduce their stress levels.

People with a history of substance abuse

Research has shown that people with a past history of substance abuse are more likely to attain Lyrica addiction. For them, any substance with even the slightest euphoric properties can trigger addiction.

People with mental health issues

Lyrica or pregabalin helps treat anxiety and insomnia, two common issues that almost every person with a mental health disorder face. Such people are more likely: to abuse Lyrica for self-medication.

Lyrica withdrawal symptoms are incredibly uncomfortable and similar to those that occur during withdrawal from alcohol and benzodiazepines. The severity of these symptoms and duration depends on the frequency and longevity of Lyrica use. There is no reliable one- or two-week recovery timetable. Symptoms and the pace of dose reduction vary with treatment history, health, and individual response.

Withdrawal may follow a dose reduction or stopping, and can be severe or prolonged. Do not stop pregabalin abruptly; agree a gradual, symptom-led reduction with the prescriber. Seizures need emergency care. Suicidal thoughts need urgent assessment, and immediate danger or inability to stay safe requires emergency help. Some common Lyrica withdrawal symptoms include:

  • Headaches
  • Agitation
  • Mood changes
  • Depression
  • Confusion
  • Anxiety
  • Suicidal thoughts
  • Sweating
  • Nausea
  • Seizures
  • Diarrhea
  • Strong cravings for Lyrica
  • Increased heart rate
  • Insomnia

Every addiction rehab has its processes and procedures, and what is applicable for one may not apply to another. In general, an individual who enters rehab receives a full psychological and physical assessment, following which a formal addiction treatment program commences. Treatment may include supported withdrawal when appropriate, together with care for addiction or other clinical needs. Withdrawal management is not simply drug clearance and does not by itself treat addiction.

During Lyrica detox, most people undergo withdrawal along with its uncomfortable symptoms. Clinicians should plan gradual dose reductions and adjust them to symptoms, while reviewing pain, anxiety, epilepsy, and other treatment needs. The setting and monitoring depend on individual risks; residential detox is not required for everyone.

The medicines discussed below are not a standard pregabalin withdrawal regimen. Any additional medication requires an individual clinical assessment of benefits, harms, and interactions:

Clonidine

Clonidine is not an established routine treatment for pregabalin withdrawal. Any off-label use requires specialist assessment and monitoring.

Dexmedetomidine

Dexmedetomidine is a sedative requiring continuous monitoring because it can lower blood pressure and heart rate. It is not a routine next step after clonidine for pregabalin withdrawal.

Sleeping Aids

Insomnia is one of the most common withdrawal side effects of Lyrica. Treatment should be individualized; trazodone or another sedating medicine should not be assumed to be a routine or risk-free withdrawal treatment.

Miscellaneous

Other medicines may be appropriate for a separately assessed symptom or condition, but there is no universal combination of medicines for pregabalin withdrawal.

Following detoxification, most people enter formal treatment to overcome the psychological aspect of their Lyrica addiction. Such treatment may take place in any one or both of the following levels.

Inpatient Treatment

Inpatient programs typically continue for one to three months and include a holistic and conventional treatment plan that involves regular therapy, comprehensive fitness and diet plans, and more. This program requires clients to stay on-site in specified accommodations where they can recover peacefully and securely among other people with similar issues. The staff members are available for help and support round the clock and adopt a non-judgmental and compassionate approach to encourage healing. Once an inpatient treatment program concludes, many people transition into outpatient treatment, a lesser-intensive treatment program.

Outpatient Treatment

Outpatient treatment also takes place on-site but differs from inpatient programs as it does not restrict the clients from leaving their homes and residing inside the rehab. These programs are less-intensive and more flexible to accommodate people with real-life obligations and duties, like childcare and hectic jobs. The appropriate setting depends on medical and psychiatric risks, substance use, available support, and the person’s treatment needs; a clinician should assess these together.

After the completion of formal rehabilitation treatment, most treatment centers offer aftercare services for up to one year to maintain long-term sobriety and recovery.

Questions

Frequently Asked Questions

Can Lyrica make you high?
Lyrica or pregabalin does not usually produce a high or euphoria similar to that produced by other painkillers, like oxycodone. However, it does induce a feeling of relaxation, which, along with pain relief, allows people to depart from the everyday reality of pain and take a break. So, some experts believe this relaxation is highly associated with Lyrica.
Why is pregabalin addictive?
Categorized as a schedule 5 drug, Lyrica is not highly addictive as other painkillers, like morphine and oxycodone. However, because it is still on the list, it automatically means that the medication carries risks of misuse, physical dependence, and addiction; physical dependence does not inevitably become addiction. Most people do not develop any chemical addiction or physical dependence on it. However, its pain relief effects and associated feelings of relaxation may make others think that they need Lyrica to survive on a day-to-day basis.
How long does it take to develop Lyrica addiction?
While it is generally safe to use Lyrica, a small number of people are at risk of abusing and becoming addicted to it. The exact amount of time it may take to develop this addiction varies from one person to another. However, in most cases, it requires consistent use over a considerable amount of time. One of the most important key factors determining this time duration is the amount of Lyrica one consumes daily. If they are increasing their daily dosage over time or are taking the medication more frequently than prescribed, addiction is likely to occur sooner than expected. Similarly, people who have a family or personal history of addiction are also at a greater risk of developing a dependence on Lyrica more quickly than others.
How long does pregabalin stay in the body?
Pregabalin is eliminated mainly unchanged through the kidneys. Its average half-life is about 6.3 hours in people with normal kidney function; reduced kidney function can prolong elimination. It does not persist for weeks because it is stored in fat. Lyrica withdrawal side effects reflect adaptation to treatment and do not simply follow the amount of drug remaining in the body.
Can I mix Lyrica with other substances?
Mixing Lyrica with other substances, including opioids, alcohol, benzodiazepines, and barbiturates, can be extremely dangerous as it significantly increases the risk of an overdose. Most of these substances act as central nervous system depressants and can, therefore, severely amplify the effects of Lyrica.
What are some common side effects of taking Lyrica?
Because of its relaxing effects on the body, many people consider Lyrica as an alternative to valium. However, it is crucial to keep in mind that along with all its possible benefits, this medication is capable of causing multiple dangerous side effects, especially in someone who is abusing it. These side effects include:
Constipation
Blurred vision
Confusion and agitation
Hallucinations
Swelling of hands and feet 
Dizziness
Loss of coordination
Drowsiness
Depression
Dry mouth
Suicidal ideation

Editorial evidence

Evidence & sources

Selected clinical guidelines, peer-reviewed research, and public-health sources used in this article.

01MedlinePlus. (2024). Pregabalin. National Library of Medicine.View source
02National Health Service. (2022). Pregabalin: About pregabalin. National Health Service.View source
03National Institute on Drug Abuse. (2024). Drugs, brains, and behavior: The science of addiction. National Institutes of Health.View source
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05National Center for Biotechnology Information. (n.d.). Pes Planus – StatPearls – NCBI Bookshelf.View source
06Molero, Y., Larsson, H., Du2019Onofrio, B. M., Sharp, D. J., & Fazel, S. (2019). Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: Population based cohort study in Sweden. The BMJ.View source
07American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders (5th ed., text rev.; DSM-5-TR). American Psychiatric Publishing.View source
08Schjerning, O., Rosenzweig, M., Pottegu00e5rd, A., Damkier, P., Nielsen, J., & Lublin, H. (2016). Abuse potential of pregabalin: A systematic review. *CNS Drugs, 30*(1), 9u201325.View source
09Finding Help for Co-Occurring Substance Use and Mental Disorders – National Institute of Mental Health (NIMH). (www.nimh.nih.gov).View source
10World Health Organization. (2019). *International classification of diseases for mortality and morbidity statistics (11th Revision)*.View source
11National Institute for Health and Care Excellence. (2021). *Neuropathic pain in adults: Pharmacological management in non-specialist settings (CG173)*.View source
12National Center for Biotechnology Information. (n.d.). Pregabalin – StatPearls – NCBI Bookshelf.View source
13Evoy, K. E., Morrison, M. D., & Saklad, S. R. (2017). Abuse and misuse of pregabalin and gabapentin: A systematic review. *Drugs, 77*(4), 403u2013426.View source
14Cochrane Pain, Palliative and Supportive Care Group. (2019). Pregabalin for neuropathic pain in adults. Cochrane Library.View source
15Gomes, T., Greaves, S., van den Brink, W., et al. (2020). Pregabalin and the risk for opioid-related death: A nested case-control study. JAMA Network Open.View source
16Drug Enforcement Administration. (2020). *Drug scheduling*.View source
What this includes
01

Clinical context

Clear information is framed around complex and co-occurring presentations.

02

Individual factors

Assessment remains essential because needs and risks differ from person to person.

03

Next steps

A confidential conversation can help clarify the most appropriate route forward.

Not sure where the situation fits?

Your admissions team

Jil Moore
Jil MooreClient Relations Director
Cynthia Nakhle
Cynthia NakhleAdmissions Manager

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