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Clinical resource

Drugs That Induce Psychosis

Drug-induced psychosis can involve hallucinations, delusions and confusion during intoxication, withdrawal or medication use. Learn the warning signs, why symptoms can persist, and when urgent medical care is needed.

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Quick Summary

  • Drug-induced psychosis needs prompt clinical assessment. Symptoms may persist or recur after intoxication ends; do not assume they will wear off. Seek emergency help if someone cannot remain safe or has possible overdose or dangerous withdrawal. Do not abruptly stop prescribed medicines or dependent alcohol/benzodiazepine use without medical advice.

Psychosis is a mental condition marked by hallucinations and delusions that causes a disconnection from reality.  Hallucinations are sensory distortions that occur without the presence of an actual external stimulus.  They might be aural, olfactory, visual, or related to any other sensory modality.  A delusion is a mistaken perception of reality that an individual clings to despite the availability of opposing evidence.  Psychosis can occur at different ages and has several possible causes. New hallucinations or delusions need prompt medical assessment; seek emergency help if someone cannot remain safe.

Psychotic symptoms can arise in the context of a variety of mental health conditions as well as substance abuse.  Psychotic episodes can occur in schizophrenia and bipolar disorder.  Psychosis can also be linked with alcohol or drug abuse in some cases.  LSD, peyote, PCP, and magic mushrooms may be the first drugs that spring to mind when thinking of hallucinogenic drugs.  Drug-related psychotic symptoms may occur during intoxication or withdrawal, and occasionally as an adverse effect of a prescribed medicine. They are not limited to prolonged use or large doses; risk varies with the substance and the person. If dependent on alcohol or benzodiazepines, seek medical advice before stopping because withdrawal can be dangerous. Do not stop prescribed medicines abruptly.

In some circumstances, psychosis is caused by the withdrawal from a substance rather than the main intoxication.  Some types of substance abuse may also increase the likelihood of developing schizophrenia in people who are predisposed to it.  A higher psychotic response to certain substances, such as LSD, may be linked to having a hereditary predisposition for schizophrenia development.

Substance use disorders can co-occur with psychosis. Observational findings vary between populations and do not establish that every psychotic episode is caused by substance use.  These types of studies highlight the link between substance addiction and psychosis.  When substance abuse or withdrawal causes psychotic symptoms, crisis intervention techniques and medical detox may be required.

Certain psychoactive substances can trigger or worsen psychotic symptoms. Different substances and combinations carry different risks; not every medicine has the same effect.  Alcohol, cocaine, amphetamines, hallucinogens, opioids, marijuana, and sedative-hypnotics are all substances that can lead to or produce psychosis.

Psychosis is a mental health condition characterized by the inability to distinguish between thoughts, reality, and perceptions.  Drug-induced psychosis may involve delusions, hallucinations in different sensory modalities, disorganized thinking and changes in behavior.  This makes it difficult for him to tell the difference between what is genuine and what is a product of his or her own thoughts.

Some people use hallucinogenic chemicals expressly for that goal, while others have delusions or hallucinations as a side effect of a drug they were taking for another reason.  For example, psychedelics, which include LSD, magic mushrooms, and mescaline, are a type of drug that consumers use for their potential to produce hallucinations and alter perceptions.  Cocaine, on the other side, can create hallucinations, though it is rarely used for this purpose.

It’s crucial to remember that, while hallucinations and delusions are common in psychosis, they don’t always indicate the presence of psychosis.  Many people who take LSD or other psychedelic substances have these symptoms, but not full-blown psychosis, which is marked by an inability to distinguish reality from fantasy.  Insight varies. Perceptual changes during hallucinogen intoxication do not by themselves establish a psychotic disorder; a clinician must assess the symptoms, safety and other possible causes.

How Long Does Drug-Induced Psychosis Last?

Drug-induced psychosis may resolve after intoxication or withdrawal, but symptoms can persist or recur and need ongoing assessment. Duration varies; do not wait for the drug to wear off before seeking care.  It is, however, a highly significant symptom that frequently necessitates immediate medical attention.  Psychosis can increase the risk of self-harm or suicide. Seek immediate emergency help if someone may harm themselves or cannot remain safe.

Symptoms may begin abruptly or develop over time. Their onset and severity depend on the substance, dose, withdrawal, other medicines and individual susceptibility.  Psychoactive substance use can worsen existing symptoms or increase the risk of psychotic episodes in some people, but the effect is not inevitable and cannot be predicted from a diagnosis alone.  Even if you aren’t diagnosed with a co-occurring mental condition, heavy drug and alcohol use might lead to psychotic symptoms.

The following are some of the signs and symptoms of drug-induced psychosis:

  • Paranoia
  • Visual and auditory hallucinations
  • Delusions
  • Anxiety attacks
  • Changes in behavior or agitation
  • Confusion

Symptoms of Delusion

Delusions occur when you think and feel something is happening that is not reflective of reality, and you dismiss any objections to these views from others because it feels genuine to you.

Delusions can take many forms, including:

  • Persecution delusions are when you think someone is watching you.
  • Jealousy delusions frequently involve a partner, in which you assume they have been disloyal despite the lack of evidence.
  • Grandiose delusions occur when you have an inflated sense of power, such as believing you have magical talents or have made a significant discovery.

Symptoms of Hallucination

The sensory judgments of what is going on around you are warped in hallucinations.  They are most commonly associated with visual or auditory changes, although they can also be linked to smell and touch.

Hallucinations come in a variety of shapes and sizes, including:

  • Hearing voices, like a voice recounting your movements or deeds, or two independent voices disagreeing with each other, are examples of auditory hallucinations.
  • Visual hallucinations are disturbing because they occur when you experience a different reality than others, with shadows, objects, and people that aren’t really there.

Can drug-induced psychosis be permanent?

Psychotic symptoms may resolve, persist or recur after drug use stops. Longer-lasting symptoms need reassessment for other causes, including a primary psychotic disorder. A treatment plan should consider prescribed medicines and alcohol or other drug use.

Substance-induced psychosis is a mental health disorder in which the beginning of psychotic episodes or signs of the psychotic disorder can be linked to the use of a drug or alcohol (onset during withdrawal or onset during intoxication).  You might have psychotic episodes only when you’re using or only when you’re not.  It’s possible that you’ll get this disorder while recovering from a substance use problem.

When you have a psychotic disorder, you may lose your capacity to distinguish between what is genuine and what isn’t.  The impact of alcohol or any drug you may be doing can exacerbate this sense of separation from reality.  The substance-induced psychotic disorder is a serious illness that necessitates medical treatment.

If you or a dear one is having a psychotic episode, see your doctor for testing and information about treatment options.  While not everyone has a psychotic episode, in the same way, certain signs and symptoms can indicate that you or someone you care about is having one, including:

  • Seeing, hearing, or smelling things that aren’t there are known as hallucinations.
  • Delusions can include believing that you are being watched or listened to despite evidence to the contrary.
  • Religious delusions, such as believing that a deity is communicating with you in a specific way
  • Problems separating fantasy from reality, such as picturing a close relationship with a superstar
  • Problems with self-care, such as forgetting to bathe and eat, or hoarding items
  • Paranoia and suspicion, including suspicions that loved ones, organizations, or others are attempting to hurt you or are “out to get you.”
  • Difficulty speaking clearly, including stuttering and disorganized speech
  • Sound, odor, or other sensory stimulation causes hypersensitivity.
  • A lack of emotional reactions or a bland affect

In persons who are already predisposed to schizophrenia, drug use, particularly overuse or misuse, is thought to induce symptoms.  Many persons who abuse methamphetamines, for example, develop psychotic symptoms as a result of their drug usage.  In these settings, drug-induced paranoia is prevalent.  Substance-induced psychosis and schizophrenia are distinct diagnoses. A person with schizophrenia may also experience a substance-related worsening of symptoms; timing alone does not determine the diagnosis.  This drug-induced psychosis can cause a recurrence in persons who are being managed for and recovering from previous bouts of schizophrenia.

This can happen to anyone, whether or not they are aware of their schizophrenia.  As a result, it may appear that people who have drug-induced schizophrenia symptoms are developing mental illness as a result of their drug use.  It should not be assumed that everyone who experiences drug-related psychosis already had schizophrenia. Assessment and follow-up help distinguish substance effects from a primary psychotic disorder.

Assessment considers the timing of substance exposure, medical and psychiatric history, symptoms and course after intoxication or withdrawal. Duration alone does not distinguish substance-induced psychosis from schizophrenia. Follow-up matters because some people later receive a different diagnosis (Rognli et al., 2023).  Some people initially diagnosed with substance-induced psychosis later receive a diagnosis of schizophrenia or another primary psychotic disorder. Risk varies and cannot be explained by a simple inherited-versus-not-inherited distinction.

Genetic susceptibility, the substance involved and other individual factors may contribute to risk, but there is no reliable binary genetic rule separating people who do and do not later develop schizophrenia.  Substance use can trigger or worsen psychotic symptoms, and some exposures are associated with increased risk of a later schizophrenia diagnosis. An individual episode needs clinical assessment rather than a categorical claim about causation.

Unfortunately, schizophrenia continues to be widely misunderstood and stigmatized.  People suffering from this mental disease would be better able to seek the therapy they need and deserve if more and more reliable information was provided.  Substance use may contribute to the onset or recurrence of psychosis. Clinicians distinguish a substance-induced episode from schizophrenia by considering the whole history and clinical course, not by assuming either inevitable causation or no possible contribution.  The informal phrase “drug-induced schizophrenia” should not replace a clinical diagnosis.

Regardless of whether a drug-induced schizophrenic episode occurs or not, a considerable percentage of people with schizophrenia consume drugs, which can lead to the recurrence of schizophrenic symptoms or make them worse.  This is why dual diagnosis treatment is so important for those who have both of these issues.

Treatment must tackle both mental illness and drug usage in order to help those who truly need it.  Dual diagnosis treatment allows you to do just that.  Some people use alcohol or drugs to cope with distress. Care should address both substance use and mental health needs without blame.  As a result, in order to successfully refrain from drug and alcohol consumption, it is required to address both the mental disease and the substance usage.  It’s doubtful that a person would make a full recovery if only the addiction or mental disease is addressed because there will be other residual problems linked with the untreated condition.

You must understand the severity of drug-induced psychosis.  It’s a bad idea to assume the person will be fine once they’ve come down from their high.  Psychotic outbursts caused by drugs can be quite harmful.  Several persons who have had similar experiences say they have seriously pondered suicide.

A drug-induced psychosis requires immediate medical attention.  If the person refuses care, remain calm, avoid confrontation or physical force, and seek urgent advice from a clinician or emergency service. Call local emergency services if there is immediate danger or they cannot remain safe.

A healthcare professional can provide drugs to someone who is suffering from drug-induced psychosis.  These drugs lessen the severity of certain symptoms, particularly dangerous hallucinations.

Some of the most fundamental things you can do to assist someone suffering from drug-induced psychosis is:

  • Allow the person to speak without being interrupted.
  • Avoid making quick judgments.
  • Inquire about what might make them feel better.
  • Allow the individual to communicate at their own pace.

After you’ve obtained all of the information, you can contact an outside source for assistance with the next stages.  Call local emergency services if there is immediate danger of self-harm or harm to others, or the person cannot remain safe.  If there is no immediate danger, contact a clinician or mental health service promptly. Apparent calm does not rule out serious symptoms or the need for assessment.  The sooner the person receives the necessary assistance, the better.

It’s also important to keep in mind that this might not be a one-time occurrence.  Symptoms of drug-induced psychosis might last for years in some persons.  Persistent hallucinations require clinical reassessment and ongoing support; individual recovery stories do not establish a typical duration.  It’s possible that you’ll need to keep talking about psychosis and hallucinations long after the person is sober.  You can provide a great lot of aid and comfort to the person you love by acting as a trusted outsider, and this could be crucial to their rehabilitation.

What to Avoid

Psychosis is a serious and dangerous condition.  That is to say, you should not dismiss anything the other person says during the interaction.  Although the thoughts and experiences described by the individual may not appear genuine to you, they are extremely real to the person with whom you are conversing.  Take those remarks seriously and make sure you take the necessary steps to protect the individual you care about and your community.

It’s also important to remember that warning signs, even if they’re subtle or slow to appear, should not be ignored.  Psychosis does not always manifest itself in the form of strong, obvious symptoms.  You might only notice a minor change in behavior.  Taking action on those minor modifications could be crucial in halting the damage before it becomes too severe to control.

Steps to Take Next

When someone you care about is suffering from psychosis, as previously stated, you should seek help.  Do not rely on home care or waiting for intoxication to end. Some episodes resolve, but prompt clinical assessment is needed and persistent or recurring symptoms require follow-up.  Someone suffering from drug-induced psychosis need treatment to quit using the drugs, as well as ongoing support to deal with the symptoms when they reappear.

When someone in your family exhibits these symptoms, you must seek treatment for them.  The police may be able to assist you in some circumstances.  Medical professionals are also required in some cases.  Do not be frightened to seek assistance.  The person you care about is counting on you.

Psychosis

Questions

Frequently Asked Questions

Does Fentanyl Cause Psychosis?
Hallucinations have been reported with opioids, including fentanyl, but are uncommon and need assessment for medication effects, delirium and other medical or psychiatric causes.  Fentanyl’s major acute danger is potentially fatal overdose. If someone is hard to wake or has slow, irregular or absent breathing, call emergency services immediately and give naloxone if available, following its instructions.  Naloxone reverses opioid overdose; it does not treat every cause of hallucinations. Emergency assessment is still needed, and prescribed opioid treatment should not be stopped abruptly without medical advice.
How Long Does LSD Cause Psychosis?
The duration of psychotic symptoms after LSD varies. Symptoms can persist or recur after the immediate intoxication has ended.  Do not assume that symptoms will end within a few hours.
Persistent or recurring hallucinations or delusions need prompt clinical assessment.  Timing alone cannot prove that LSD caused the symptoms. Assessment should consider other substances, medicines, medical illness and a possible primary psychotic disorder.
What Drugs Cause Paranoia?
Numerous drugs, notably alcohol, marijuana, meth, cocaine, bath salts, and LSD are linked to paranoia during withdrawal and intoxication.
When a person is inebriated, he is more inclined to believe that everyone else is against them.  Paranoia alone does not determine how someone will behave. Respond calmly and seek urgent clinical assessment; call emergency services if there is immediate danger, severe confusion or possible dangerous withdrawal.

Editorial evidence

Evidence & sources

Selected clinical guidelines, peer-reviewed research, and public-health sources used in this article.

01National Alliance on Mental Illness. (n.d.). Psychosis. National Alliance on Mental Illness.View source
02National Institute of Mental Health. (n.d.). Understanding psychosis. National Institute of Mental Health.View source
03National Health Service. (n.d.). Psychosis. National Health Service.View source
View all 10 sourcesShow fewer sources
04National Institute on Drug Abuse. (n.d.). Hallucinogens. National Institute on Drug Abuse.View source
05National Institute on Drug Abuse. (n.d.). Cocaine. National Institute on Drug Abuse.View source
06National Institute on Drug Abuse. (n.d.). Methamphetamine. National Institute on Drug Abuse.View source
08National Health Service. (n.d.). Causes – psychosis.View source
09American Psychiatric Association. (n.d.). What is schizophrenia? American Psychiatric Association.View source
10World Health Organization. (n.d.). Schizophrenia. World Health Organization.View source
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Clear information is framed around complex and co-occurring presentations.

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Jil MooreClient Relations Director
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Cynthia NakhleAdmissions Manager

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